ICD-10-CM › D50-D89 › D80-D89 › D codes › D81

D81

Combined immunodeficiencies

Not billableICD-10-CM diagnosis code.

This code exists but cannot be submitted on its own. It groups the more specific codes beneath it.

A category header for its whole life, FY2016 onwards. It has never been valid for submission on its own.

Submit one of these 10 more specific codes instead:

  • D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
  • D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
  • D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
  • D81.3 Adenosine deaminase [ADA] deficiency (also a header)
  • D81.4 Nezelof's syndrome
  • D81.5 Purine nucleoside phosphorylase [PNP] deficiency
  • D81.6 Major histocompatibility complex class I deficiency
  • D81.7 Major histocompatibility complex class II deficiency
  • D81.8 Other combined immunodeficiencies (also a header)
  • D81.9 Combined immunodeficiency, unspecified

What has happened to this code

Every change the publisher made, from 2012 to now. Entries marked draft are from the pre-implementation releases: ICD-10 took effect on 1 October 2015, so nothing before FY2016 was ever valid on a claim.

  1. FY2012 Added to the draft code set draft Combined immunodeficiencies

Official coding rules

Published by CDC for FY2027. A rule attached to a category binds every code beneath it, so the rules inherited from this code's ancestors are shown with the code they come from.

This code

Excludes1 - never coded here

  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Inherited from the D80-D89 section Certain disorders involving the immune mechanism (D80-D89)

Excludes1 - never coded here

  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)

Excludes2 - not included here

  • human immunodeficiency virus [HIV] disease (B20)

Includes

  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis