Obesity due to disruption of MC4R pathway

ValidICD-10-CM diagnosis code.

Valid for claims with a date of service in the current code year.

Valid FY2025 onwards.

What has happened to this code

Every change the publisher made, from 2025 to now.

FY2025 Added to the code set Obesity due to disruption of MC4R pathway

Official coding rules

Published by CDC for FY2027. A rule attached to a category binds every code beneath it, so the rules inherited from this code's ancestors are shown with the code they come from.

Inherited from E88 Other and unspecified metabolic disorders

Excludes1 - never coded here

histiocytosis X (chronic) (C96.6)

Use additional code

codes for associated conditions

Inherited from the E70-E88 section Metabolic disorders (E70-E88)

Excludes1 - never coded here

androgen insensitivity syndrome (E34.5-)
congenital adrenal hyperplasia (E25.0)
hemolytic anemias attributable to enzyme disorders (D55.-)
Marfan syndrome (Q87.4-)
5-alpha-reductase deficiency (E29.1)

Excludes2 - not included here

Ehlers-Danlos syndromes (Q79.6-)

How CDC's index refers to this code

Wording from the official alphabetic index. Much of it appears nowhere in the code description, which is why a search for the everyday phrase so often finds nothing.

Fatness
Adiposis
Adiposity
Corpulence
Fat > excessive
Excess, excessive, excessively > fat
Obesity > due to > gene mutation > leptin
Obesity > due to > disruption of MC4R pathway
Obesity > due to > gene mutation > leptin receptor
Obesity > due to > gene mutation > proopiomelanocortin
Obesity > due to > gene mutation > melanocortin 4 Receptor
Obesity > due to > gene mutation > nuclear receptor coactivator 1
Obesity > due to > gene mutation > src homology 2B adaptor signaling protein
Obesity > due to > gene mutation > proprotein convertase subtilisin/kexin type 1

Codes in the same group

Code	Description	Status
E88.81	Metabolic syndrome and other insulin resistance	Not billable
E88.89	Other specified metabolic disorders	Valid