Cytokine release syndrome

Not billableICD-10-CM diagnosis code.

This code exists but cannot be submitted on its own. It groups the more specific codes beneath it.

A category header for its whole life, FY2021 onwards. It has never been valid for submission on its own.

Submit one of these 6 more specific codes instead:

D89.831 Cytokine release syndrome, grade 1
D89.832 Cytokine release syndrome, grade 2
D89.833 Cytokine release syndrome, grade 3
D89.834 Cytokine release syndrome, grade 4
D89.835 Cytokine release syndrome, grade 5
D89.839 Cytokine release syndrome, grade unspecified

What has happened to this code

Every change the publisher made, from 2021 to now.

FY2021 Added to the code set Cytokine release syndrome

Official coding rules

Published by CDC for FY2027. A rule attached to a category binds every code beneath it, so the rules inherited from this code's ancestors are shown with the code they come from.

Inherited from D89 Other disorders involving the immune mechanism, not elsewhere classified

Excludes1 - never coded here

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 - not included here

transplant failure and rejection (T86.-)

Inherited from the D80-D89 section Certain disorders involving the immune mechanism (D80-D89)

Excludes1 - never coded here

autoimmune disease (systemic) NOS (M35.9)
functional disorders of polymorphonuclear neutrophils (D71-)

Excludes2 - not included here

human immunodeficiency virus [HIV] disease (B20)

Includes

defects in the complement system
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
sarcoidosis

Codes in the same group

Code	Description	Status
D89.81	Graft-versus-host disease	Not billable
D89.82	Autoimmune lymphoproliferative syndrome [ALPS]	Valid
D89.84	IgG4-related disease	Valid
D89.89	Other specified disorders involving the immune mechanism, not elsewhere classified	Valid