Releases › HCPCS Level II October 2025

HCPCS Level II October 2025

Effective 2025-10-01 to 2025-12-31. 8,846 codes in the release.

76added
12revised
7removed

Codes added 76

CodeDescription
A2036 Cohealyx collagen dermal matrix, per square centimeter
A2037 G4derm plus, per milliliter
A2038 Marigen pacto, per square centimeter
A2039 Innovamatrix fd, per square centimeter
A4288 Valve for breast pump, replacement
A9612 Injection, fluorescein, 1 mg
A9616 Gallium ga-68 gozetotide (gozellix), diagnostic, 1 millicurie
C1740 Leadless electrode, transmitter, battery (all implantable), for sequential left ventricular pacing
C1741 Anchor/screw for bone fixation, absorbable (implantable)
C1742 Pressure monitoring system, compartmental intramuscular (implantable), continuous, including all components (e.g., introducer, sensor), excludes mobile (wireless) software application
C8006 Insertion of pleural-peritoneal shunt with intercostal pump chamber, including imaging, injection(s) of contrast with radiological supervision and interpretation, when performed
C9305 Injection, nipocalimab-aahu, 3 mg
C9306 Injection, telisotuzumab vedotin-tllv, 1 mg
E0150 Combination wheeled walker with seat and transport chair, folding, adjustable or fixed height
E0658 Segmental pneumatic appliance for use with pneumatic compressor, integrated, 2 full arms and chest
E0659 Segmental pneumatic appliance for use with pneumatic compressor, integrated, head, neck and chest
J0163 Injection, epinephrine in sodium chloride (endo), 0.1 mg
J0164 Injection, epinephrine in sodium chloride (baxter), 0.1 mg
J0458 Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg)
J0462 Injection, atropine sulfate, not therapeutically equivalent to j0461, 0.01 mg
J0525 Injection, cefotetan disodium, 10 mg
J0582 Injection, bivalirudin (endo), not therapeutically equivalent to j0583, 1 mg
J0614 Injection, treosulfan, 50 mg
J0668 Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
J0675 Injection, carboprost tromethamine, 0.1 mg
J0681 Injection, ceftobiprole medocaril sodium, 3 mg
J0738 Injection, lenacapavir, 1 mg, fda approved prescription, only for use as hiv pre-exposure prophylaxis (not for use as treatment for hiv)
J0752 Oral, lenacapavir, 300 mg, fda approved prescription, only for use as hiv pre-exposure prophylaxis (not for use as treatment for hiv)
J0759 Injection, clevidipine butyrate, 1 mg
J1370 Injection, esomeprazole sodium, 1 mg
J1612 Injection, glucagon (gvoke), 0.01 mg
J1807 Injection, ethacrynate sodium, 1 mg
J1809 Injection, fosdenopterin, 0.1 mg
J1834 Injection, isoniazid, 1 mg
J2151 Injection, mannitol, 250 mg
J2291 Injection, nafcillin sodium (baxter), 20 mg
J3290 Injection, tranexamic acid, 5 mg
J3402 Injection, remestemcel-l-rknd, per therapeutic dose
J3403 Revakinagene taroretcel-lwey, per implant
J7173 Injection, concizumab-mtci, 0.5 mg
J7174 Injection, fitusiran, 0.04 mg
J9011 Injection, datopotamab deruxtecan-dlnk, 1 mg
L1007 Scoliosis orthosis, sagittal-coronal control provided by a rigid lateral frame, extends from axilla, to trochanter, includes all accessory pads, straps, and interface, custom fabricated
L5657 Addition to lower extremity prosthesis, manual/automated adjustable air, fluid, gel or equal socket insert for limb volume management, any materials
L6034 Partial hand, finger, and thumb prosthesis without prosthetic digit(s)/thumb, amputation at distal to metacarpal joint, including flexible or non-flexible interface, molded to patient model, for use without external power and/or passive prosthetic digit/thumb, not including inserts described by l6692
L6035 Single prosthetic digit, mechanical, can include metacarpophalangeal (mcp), proximal interphalangeal (pip), and/or distal interphalangeal (dip) joint(s), with or without locking mechanism, can include flexion or extension assist, any material, attachment, initial issue or replacement
L6036 Prosthetic thumb, mechanical, can include metacarpophalangeal (mcp), interphalangeal (ip) joint(s), with or without locking mechanism, can include flexion or extension assist, any material, attachment, initial issue or replacement
L6038 Addition to single prosthetic digit or thumb, mechanical, attachment, multiaxial and/or internal/external rotation/abduction/adduction mechanism, with or without locking feature, any material
L6039 Passive prosthetic digit or thumb prosthesis not including hand restoration partial hand, full or partial, custom made, any material, initial or replacement, per single passive prosthetic digit or thumb
M0235 Intravenous infusion, monoclonal antibody products with an indication for post-exposure prophylaxis or treatment of covid-19, for hospitalized adults and/or pediatric patients who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, not otherwise classified, first dose
M0236 Intravenous infusion, monoclonal antibody products with an indication for post-exposure prophylaxis or treatment of covid-19, for hospitalized adults and/or pediatric patients who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, not otherwise classified, second dose
M0237 Intravenous infusion, tocilizumab-anoh, for hospitalized adult patients with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, first dose
M0238 Intravenous infusion, tocilizumab-anoh, for hospitalized adult patients with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, includes infusion and post administration monitoring, second dose
Q0235 Injection, monoclonal antibody products with an indication for post-exposure prophylaxis or treatment of covid-19, for hospitalized adults and/or pediatric patients who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, not otherwise classified, 1 mg
Q0237 Injection, tocilizumab-anoh, for hospitalized adult patients with covid-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ecmo) only, 1 mg
Q4383 Axolotl graft ultra, per square centimeter
Q4384 Axolotl dualgraft ultra, per square centimeter
Q4385 Apollo ft, per square centimeter
Q4386 Acesso trifaca, per square centimeter
Q4387 Neothelium ft, per square centimeter
Q4388 Neothelium 4l, per square centimeter
Q4389 Neothelium 4l+, per square centimeter
Q4390 Ascendion, per square centimeter
Q4391 Amnioplast double, per square centimeter
Q4392 Grafix duo, per square centimeter
Q4393 Surgraft ac, per square centimeter
Q4394 Surgraft aca, per square centimeter
Q4395 Acelagraft, per square centimeter
Q4396 Natalin, per square centimeter
Q4397 Summit aaa, per square centimeter
Q5154 Injection, omalizumab-igec (omlyclo), biosimilar, 5 mg
Q5155 Injection, aflibercept-jbvf (yesafili), biosimilar, 1 mg
Q5156 Injection, tocilizumab-anoh (avtozma), biosimilar, 1 mg
Q5157 Injection, denosumab-bmwo (stoboclo/osenvelt), biosimilar, 1 mg
Q5158 Injection, denosumab-bnht (bomyntra/conexxence), biosimilar, 1 mg
Q5159 Injection, denosumab-dssb (ospomyv/xbryk), biosimilar, 1 mg

Descriptions revised 12

CodeWas, and is now
C1739 Tissue marker, probe detectable any method (implantable), with delivery system Tissue marker, uniquely detectable and identifiable with probe/sensor, any method (implantable), with delivery system
C1982 Catheter, pressure-generating, one-way valve, intermittently occlusive Catheter, pressure-generating, (e.g., one-way valve, intermittently occlusive)
E0765 Fda approved nerve stimulator, with replaceable batteries, for treatment of nausea and vomiting Fda approved nerve stimulator, for treatment of nausea and vomiting
E0986 Manual wheelchair accessory, push-rim activated power assist system Manual wheelchair accessory, power assist system
J1961 Injection, lenacapavir, 1 mg Injection, lenacapavir (only for use as hiv treatment), 1 mg
J7300 Intrauterine copper contraceptive Intrauterine copper contraceptive (paragard)
J9072 Injection, cyclophosphamide (avyxa), 5 mg Injection, cyclophosphamide (frindovyx), 5 mg
L5673 Addition to lower extremity, below knee/above knee, custom fabricated from existing mold or prefabricated, socket insert, silicone gel, elastomeric or equal, for use with locking mechanism Addition to lower extremity, below knee/above knee, custom fabricated from existing mold or prefabricated, socket insert, silicone gel, elastomeric, or equal, with or without perforations, with or without breathable material, for use with locking mechanism
L5679 Addition to lower extremity, below knee/above knee, custom fabricated from existing mold or prefabricated, socket insert, silicone gel, elastomeric or equal, not for use with locking mechanism Addition to lower extremity, below knee/above knee, custom fabricated from existing mold or prefabricated, socket insert, silicone gel, elastomeric, or equal, with or without perforations, with or without breathable material, not for use with locking mechanism
L5783 Addition to lower extremity, user adjustable, mechanical, residual limb volume management system Addition to lower extremity, user adjustable, mechanical, residual limb volume management system (with or without lamination kit)
L6028 Partial hand including fingers, flexible or non-flexible interface, endoskeletal system, molded to patient model, for use without external power, not including inserts described by l6692 Partial hand, finger, and thumb prosthesis without prosthetic digit(s)/thumb, amputation at metacarpal level, including flexible or non-flexible interface, molded to patient model, including palm, for use without external power and/or passive prosthetic digit/thumb, not including inserts described by l6692
L7406 Addition to upper extremity, user adjustable, mechanical, residual limb volume management system Addition to upper extremity prosthesis, user adjustable, mechanical, residual limb volume management system (with or without lamination kit)

Terminated 7

CodeDescription
C9088 Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
C9174 Injection, datopotamab deruxtecan-dlnk, 1 mg
C9175 Injection, treosulfan, 50 mg
C9248 Injection, clevidipine butyrate, 1 mg
J2150 Injection, mannitol, 25% in 50 ml
J2503 Injection, pegaptanib sodium, 0.3 mg
S0074 Injection, cefotetan disodium, 500 mg